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54th ERA-EDTA Congress

 

3rd-6th June 2017 Madrid
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Discussion forum - 54th ERA-EDTA Congress
    Topic - Experimental AKI I

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Poster: 160
Visits: 8
Title: LPS-MEDIATED RECRUITMENT OF MTOR COMPLEX 1 ENHANCES ENDOTHELIAL DYSFUNCTION IN SEPSIS-INDUCED ACUTE KIDNEY INJURY
Authors: Alessandra Stasi , Fabio Sallustio, Chiara Divella, Rossana Franzin, Margherita Gigante, Angela Picerno, Paola Pontrelli, Giuseppe Grandaliano, Loreto Gesualdo, Giuseppe Castellano
Centre: University of Bari

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LPS-MEDIATED RECRUITMENT OF MTOR COMPLEX 1 ENHANCES ENDOTHELIAL DYSFUNCTION IN SEPSIS-INDUCED ACUTE KIDNEY INJURY

Alessandra Stasi
Thread initiator
Subspeciality
Reg: 5/24/2017 11:03:00 PM
Comment# 1
The pathophysiology of sepsis induced-Acute Kidney Injury(AKI) is multi-factorial and includes endothelial cell (EC)dysfunction, infiltration of inflammatory cells, intra-glomerularthrombosis, and obstruction of tubules. mTOR complex 1(mTORC1) has been shown to be activated after LPS binding toToll-like receptor (TLR)-4, and it may be pivotal in renal cellactivation and in the progression of endothelial dysfunction and renal fibrosis. However, the precise signal transduction by which TLR4 activates mTOR in EC is still not known.

Comment added on 5/24/2017 11:04:00 PM 
     
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Most viewed poster for this congress
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Authors: Simic Ogrizovic Sanja ,
Centre: Serbian society of nephrology

Poster most viewed in this topic
Poster: 158
Visits: 21
Title: BCL3: AN NF-kB REGULATOR INDUCIBLE BY TWEAK IN ACUTE KIDNEY INJURY WITH ANTI-INFLAMMATORY AND ANTI-APOPTOTIC PROPERTIES IN TUBULAR CELLS
Authors: Jonay Poveda , Jonay Poveda, Ana B Sanz, Susana Carrasco, Marta Ruiz-Ortega, Pablo Cannata-Ortiz, María Dolores Sánchez-Niño, Alberto Ortiz
Centre: Universidad Autónoma de Madrid, IIS-Fundación Jiménez Diaz


 




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